Don’t wait for heartburn to strike, block it before it starts with just one Prilosec OTC pill each morning – a simple solution for 24 hour heartburn relief*. Prilosec OTC is a proton pump inhibitor (PPI) specially designed to treat frequent heartburn, the omeprazole acid reducer tablets prevent excess acid production to keep your heartburn in check, working all day & all night to provide heartburn relief for a full 24 hours*. Its active ingredient, delayed-release omeprazole 20mg, works differently from other heartburn medicine like antacids that only neutralize acid after it’s produced & provide shorter relief.